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Polynucleotides
All TreatmentsRestore & Hydrate

Polynucleotides

DNA-based skin regeneration

Highly purified DNA fragments that improve hydration and skin quality without volume addition. Polynucleotides work at a cellular level to stimulate tissue repair and regeneration — ideal for under-eyes, face, neck, and scalp.

Price
From £140
Duration
30–45 minutes
Results
1–2 weeks
Lasts
3–6 months
Downtime
Minimal

Key Benefits

1

Deep tissue repair and regeneration

2

Improves hydration and skin barrier function

3

Excellent for under-eye rejuvenation

4

No volume — purely skin quality improvement

Treatment Details

We offer three leading brands: Plinest (Mastelli, Italy) using patented PN-HPT™ technology, Vitaran (CE-marked, salmon DNA), and Rejuran (PharmaResearch, Korea) with DOT™ technology.

Treatment is typically 3–4 sessions, 2–4 weeks apart. Visible improvement begins at 1–2 weeks with continued improvement for 4–6 weeks post-treatment.

Product Range & Pricing

Treatment
Format
Best For
Price
Vitaran Eyes
1×1ml 2%
Under-eye
£140
Rejuran I
1ml 1%
Under-eyes/lips
£275
Rejuran S
1ml 2%
Scars/texture
£275
Vitaran 2ml
2×1ml 2%
Face and eyes
£180
Plinest
2ml 2%
Face/neck/décolletage
£220
Plinest Eye
2ml 0.75%
Under-eye area
£200
Plinest Hair
2ml 0.75%
Scalp/hair support
Vitaran 4ml
2×2ml 2%
Face/neck/body
£230
Rejuran Healer
2ml 2%
Full-face rejuvenation
£330

Three Leading Brands

Plinest

Mastelli, Italy — PN-HPT technology using Italian trout DNA. A pharmaceutical heritage dating back to the 1930s, delivering highly purified polynucleotides for deep tissue regeneration.

Vitaran

CE-marked polynucleotide range using salmon DNA at 20mg/ml concentration. Focused on cellular repair and regeneration, available in 3 formats for eyes, face, and body.

Rejuran

PharmaResearch Korea — DOT technology using Oncorhynchus keta salmon. Available in 3 formulations (Healer, I, and S) targeting different treatment areas and concerns.

Frequently Asked Questions

How are polynucleotides different from skin boosters?

While both improve skin quality, polynucleotides work at a deeper cellular level — stimulating DNA repair and tissue regeneration rather than just adding hydration.

Are they safe?

Yes. Polynucleotides have been used in regenerative medicine for years. The DNA fragments are highly purified from fish (salmon/trout) and are biocompatible.

Which brand is right for me?

It depends on the treatment area, your skin, and your goals. Plinest, Vitaran, and Rejuran each use different technology and concentrations. We will recommend the best option during your consultation.

Book Your Polynucleotides Consultation

Your assessment, prescription, and treatment — all with one qualified practitioner in a single, unhurried appointment.

Book a Consultation