What are polynucleotides?
Polynucleotides are short chains of DNA fragments — most commonly derived from salmon or trout — that act as bio-stimulators when injected into the skin. Once placed, they trigger fibroblast activity, modulate inflammation, and support tissue regeneration.
They are not fillers. They do not add volume. They work below the surface to improve skin quality, texture, and resilience over weeks to months.
What the evidence shows
Polynucleotides have been used in regenerative medicine for decades. The aesthetic application is newer, but research demonstrates three primary effects: fibroblast stimulation (driving collagen and elastin production), anti-inflammatory action (reducing oxidative stress and inflammatory cascades), and improved tissue oxygenation (supporting healthier skin physiology).
In practice, that translates to firmer, more luminous skin, fewer fine lines, and improved texture — particularly in delicate areas like under-eyes, neck, and décolletage.
Where they excel
Under-eye area. This is where polynucleotides have changed my practice most. The under-eye is too delicate for traditional filler in many clients, but it responds well to polynucleotides — improving thickness, reducing crepiness, and softening dark circles caused by thin skin.
Neck and décolletage. These areas are often neglected and respond beautifully to a course of polynucleotides.
Acne scarring. Particularly for atrophic scarring, polynucleotides support tissue remodelling in a way that traditional treatments don't.
Hair and scalp. Newer applications include scalp injections for early-stage hair thinning. The evidence is growing but promising.
How it compares to Profhilo
Profhilo is a hyaluronic acid bio-remodeller. Polynucleotides are DNA-fragment bio-stimulators. Both improve skin quality, but they work via different mechanisms.
Profhilo is faster — visible results within weeks. Polynucleotides are slower and more cumulative — best results often emerge after a full course of three to four sessions.
In practice, I often combine them: Profhilo for hydration and luminosity, polynucleotides for the specific areas (under-eye, neck) where Profhilo isn't the right tool.
The protocol
Most polynucleotide brands require three to four sessions spaced two to three weeks apart, with maintenance every six to nine months. Treatment takes around 30 minutes. Downtime is minimal — possibly small bumps for 24 hours.
Booking a consultation
If you're curious whether polynucleotides are right for you — particularly for under-eyes, neck, or stubborn skin texture — a consultation is the best place to start. I'll assess your skin, talk through what to expect, and tell you honestly whether they're the right call or whether something else would serve you better.